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Precautions concerning Use: Caution in administration: GLAKAY should be taken after meals because its absorption is decreased when administered to patients with an empty stomach.
The absorption of GLAKAY decreases if a meal has a low fat content, since menatotrenone is lipophilic. (See Pharmacology: Pharmacokinetics under Actions.)
Caution in handling over drug: For drugs that are dispensed in a press-through package (PTP), instruct the patient to remove the drug from the package prior to use. (It has been reported that, if the PTP sheet is swallowed, the sharp corners of the sheet may puncture the esophageal mucosa, causing perforation and resulting in serious complications such as mediastinitis).
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