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Important Precautions: If any improvement of gastrointestinal symptoms is not observed after the administration for a given period of time (usually for 2 weeks), this drug should not be administered aimlessly for a long period.
Other Precautions: When 100 to 330 times of the recommended clinical dose (30 to 100 mg/kg/day) of mosapride citrate was orally administered in rodents for long period (104 weeks in rats, 92 weeks in mice), increased incidence of hepatocellular adenoma and thyroid follicular cell adenoma were observed.
Use in Children: Safety of this drug in children has not been established [no clinical experience].
Use in the Elderly: Since in the elderly patients their physiological function in the kidneys and the liver are reduced in general, this drug should be administered with care by monitoring patients' condition. If any adverse reactions are found, appropriate measures such as reducing the dose (e.g. to 7.5 mg daily) should be given.
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