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Gabapentin should be used with caution in patients with renal impairment and in those undergoing hemodialysis, elderly, diabetes mellitus, pregnancy, breast-feeding women.
Avoid abrupt withdrawal since it may cause anxiety, insomnia, nausea, pain, and sweating. The administration should be tapered off over at least 1 week.
False positive readings h ave been reported with some urinary protein tests in patients taking gabapentin.
Gabapentin may cause CNS depression, which may impair physical or mental abilities. Patients must be cautioned about performing tasks which require mental alertness. Avoid driving, operating potential dangerous machinery while taking gabapentin.
Antiepileptics are associated with an increased risk of suicidal behavior/thoughts with use (regardless of indication); patients should be monitored for signs/symptoms of depression, suicidal tendencies, and other unusual behavior changes during therapy and instructed to inform their healthcare provider immediately if symptoms occur.
Effects with other sedative drugs or ethanol may be potentiated.
Male rat studies demonstrated an association with pancreatic adenocarcinoma (clinical implication unknown).
Pediatric patients (3-12 years of age) have shown increased incidence of CNS related adverse effects, including emotional ability, hostility, thought disorder, and hyperkinesia.
