Fytosid Dosage/Direction for Use

RECOMMENDED DOSE: The recommended dose of Etoposide is: Refractory Testicular Tumors: 50 to 100 mg/m² per day administered intravenously over 30 to 60 minutes on days 1 through 5 of each 21-day (or 28-day cycle), or 100 mg/m² administered intravenously 30 to 60 minutes on days 1, 3, and 5 of each 21-day (or 28-day cycle).
Small Cell Lung Cancer: The recommended dose of Etoposide is 35 mg/m² to 50 mg/m² per day administered intravenously over 30 to 60 minutes or longer for 4 consecutive days of each 21-day cycle.
Regimens vary; the usual intravenous dose of etoposide ranges from 50 to 120 mg/m² daily for 5 days. Somewhat lower doses have been suggested in lung cancer. Alternatively, 100 mg/m² has been given on alternate days to a total of 300 mg/m². Courses may be repeated after 3 to 4 weeks. Doses should be reduced in renal impairment.
MODE OF ADMINISTRATION: Administration in renal impairment: In patients with a creatinine clearance (CLcr) of between 15 and 50 mL/minute be given 75% of the recommended dose.
Data are not available in patients with creatinine clearance less than 15 ml/min.
Administration: Hypotension following rapid intravenous administration has been reported; hence, it is recommended that the etoposide solution be administered over a 30 to 60 minute period. A longer duration of administration may be used if the volume of fluid to be infused is a concern. Etoposide should not be given by rapid intravenous injection.
Preparation for Intravenous Administration: Etoposide Injection must be diluted prior to use with either 5% Dextrose Injection, USP or 0.9% Sodium Chloride Injection, USP to give a final concentration of 0.2 to 0.4 mg/mL. If solutions are prepared at concentrations above 0.4 mg/mL, precipitation may occur.
Leaching of the plasticiser diethylhexyl phthalate (which is potentially toxic and carcinogenic) from PVC bags and tubing has been reported with etoposide, and it has been suggested that these should also not be used if possible when preparing and giving the drug.
Etoposide Injection should not be physically mixed with any other drug.