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Experience with levetiracetam overdose is very limited. The highest known ingested dose was 6,000 mg, and drowsiness was the only symptom reported in the few known cases of overdose.
Treatment of Overdose: Note: There is no specific antidote for levetiracetam overdose.
To enhance elimination: Standard hemodialysis should be considered, particularly in selected patients based on clinical status or renal impairment. Approximately 50% of levetiracetam is removed in 4 hours.
Monitoring: Monitor vital signs and clinical status.
Supportive care: General supportive care.
Patients in whom intentional overdose is confirmed or suspected should be referred for psychiatric consultation.
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