Flexital CR Special Precautions

General: Oxpentifylline has been used safely for treatment of peripheral arterial disease in patients with concurrent coronary artery and cerebrovascular diseases, but there have been occasional reports of angina, hypotension and arrhythmia. As it is a methylxanthine derivative, it is possible some individuals will experience such responses.
Drug Interactions: There have been reports of bleeding and/or prolonged prothrombin time in patients treated with oxpentifylline with and without anticoagulants or platelet aggregation inhibitors. Patients on anticoagulants should have more frequent monitoring of prothrombin time, while patients with other risk factors complicated by hemorrhage (e.g. recent surgery, peptic ulceration) should have periodic examinations for bleeding including hematocrit and/or hemoglobin.
Periodic systemic blood pressure monitoring is recommended for patients receiving concomitant antihypertensive therapy. If indicated, dosage of the antihypertensive agents should be reduced.
Use in Pregnancy: There are no adequate and well-controlled studies in pregnant women, therefore, Flexital should be used during pregnancy only if benefit outweigh the risk.