Finil | Mechanism of Action

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Full Prescribing Info

Action

Pharmacotherapeutic Group: Angiotensin II Receptor Blocker; Antihypertensive.
Pharmacology: Pharmacodynamics: Mechanism of Action: Candesartan is an angiotensin receptor antagonist. Angiotensin II acts as a vasoconstrictor. In addition to causing direct vasoconstriction, angiotensin II also stimulates the release of aldosterone. Once aldosterone is released, sodium as well as water are reabsorbed. The end result is an elevation in blood pressure. Candesartan binds to the AT1 angiotensin II receptor. This binding prevents angiotensin II from binding to the receptor thereby blocking the vasoconstriction and the aldosterone secreting effects of angiotensin II.
Pharmacodynamics/kinetics: Onset of Action: 2-3 hours.
Peak Effect: 6-8 hours.
Distribution: Vd: 0.13 L/kg.
Protein binding: >99%.
Metabolism: Parent compound bioactivated during absorption via ester hydrolysis within intestinal wall to candesartan.
Bioavailability: 15%.
Half-life Elimination (dose dependent): 5-9 hours.
Time to peak: 3 to 4 hours.
Excretion: Urine (26%).

Finil Mechanism of Action

candesartan

Manufacturer:

Unison

Distributor:

Medline

Marketer:

B.Grimm Pharma