Ezentia Dosage/Direction for Use

General Dosing Information: The recommended dose of ezetimibe is 10 mg once daily.
Ezetimibe can be administered with or without food.
Concomitant Lipid-Lowering Therapy: Ezetimibe may be administered with a statin (in patients with primary hyperlipidemia) or with fenofibrate (in patients with mixed hyperlipidemia) for incremental effect. For convenience, the daily dose of ezetimibe may be taken at the same time as the statin or fenofibrate, according to the dosing recommendations for the respective medications.
Co-Administration with Bile Acid Sequestrants: Dosing of ezetimibe should occur either ≥2 hours before or ≥4 hours after administration of a bile acid sequestrant (see Interactions).
Patients with Hepatic Impairment: No dosage adjustment is necessary in patients with mild hepatic impairment (see Precautions).
Patients with Renal Impairment: No dosage adjustment is necessary in patients with renal impairment (see Pharmacology: Pharmacokinetics under Actions). When given with simvastatin in patients with moderate to severe renal impairment (estimated glomerular filtration rate <60 mL/min/1.73 m²), doses of simvastatin exceeding 20 mg should be used with caution and close monitoring (see Precautions).
Geriatric Patients: No dosage adjustment is necessary in geriatric patients (see Pharmacology: Pharmacokinetics under Actions).