Excessive hypotension in patients w/ Na &/or vol depletion. Severe renal impairment (GFR <30 mL/min). Concomitant use w/ K supplements, K-sparing diuretics, salt substitutes containing K or other drugs that may increase K levels (eg, heparin). Monitor K levels regularly. Patients w/ unilateral or bilateral renal artery stenosis, stenosis to a solitary kidney, kidney transplantation, serious CHF, oliguria &/or progressive azotemia, heart failure/post MI, acute MI; aortic & mitral valve stenosis, obstructive hypertrophic cardiomyopathy. Discontinue if angioedema develops. Concomitant use w/ other agents blocking the renin angiotensin system (RAS) eg, ACE inhibitors or aliskiren. Hepatic impairment or biliary obstructive disorders. Renal impairment. Childn <18 yr.
Sign Out
