Enbrel Description

Each ENBREL pre-filled syringe contains 25 mg or 50 mg of etanercept (active ingredient). Each pre-filled pen contains 50 mg of etanercept.
ENBREL (etanercept) is a dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1. The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of IgG1. Etanercept is produced by recombinant DNA technology in a Chinese hamster ovary (CHO) mammalian cell expression system. It consists of 934 amino acids and has an apparent molecular weight of approximately 150 kilodaltons.
MYCLIC is the tradename for the pre-filled pen.
Solution for injection in pre-filled syringe and pre-filled pen: The solution for injection in the pre-filled syringe and the pre-filled pen is clear to opalescent, colorless to yellow or pale brown, and liquid may contain trace levels of translucent to white amorphous particles, with a pH of 6.3 ± 0.2.
Excipients/Inactive Ingredients: The excipients in the pre-filled syringe and pre-filled pen are sucrose, sodium chloride, L-arginine hydrochloride, sodium phosphate monobasic dihydrate, sodium phosphate dibasic dihydrate, and water.