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ENANTONE L.P. 3.75 mg should not be administered to pregnant females or nursing mothers (See Contraindications).
ENANTONE L.P. 11.25 mg should not be administered to pregnant females, females having possibilities of being pregnant or nursing mothers. [Abortion due to GnRH derivatives has been reported. In animal studies of this drug, increased fetal death rate and low fetal body weight were observed (in rats and rabbits), and an increasing tendency for abnormal formation of fetal skeleton was observed (in rabbits). The transfer of Leuprorelin Acetate to mother's milk was also observed in rats.]
ENANTONE L.P. 30 mg is not intended for the use in females and is generally contraindicated during pregnancy and lactation.
Fertility in men: Clinical and pharmacological studies in men showed that the depression of fertility was completely reversible 24 weeks at the latest after discontinuation of continuous leuprorelin acetate application.
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