Eliquis Dosage/Direction for Use

ELIQUIS can be taken with or without food.
If a dose is missed, the patient should take ELIQUIS immediately and then continue with twice daily administration as before.
Prevention of VTE: Elective Hip or Knee Replacement Surgery: The recommended dose of ELIQUIS is 2.5 mg taken orally twice daily. The initial dose should be taken 12 to 24 hours after surgery.
In patients undergoing hip replacement surgery, the recommended duration of treatment is 32 to 38 days.
In patients undergoing knee replacement surgery, the recommended duration of treatment is 10 to 14 days.
Prevention of Stroke and Systemic Embolism: NVAF: The recommended dose of ELIQUIS is 5 mg taken orally twice daily.
Age, body weight, serum creatinine: In patients with at least 2 of the following characteristics, age ≥80 years, body weight ≤60 kg, or serum creatinine ≥1.5 mg/dL (133 micromole/L), the recommended dose of ELIQUIS is 2.5 mg twice daily.
Treatment of DVT and PE: The recommended dose of ELIQUIS is 10 mg taken orally twice daily for 7 days, followed by 5 mg taken orally twice daily.
Prevention of recurrent DVT and PE: The recommended dose of ELIQUIS is 2.5 mg taken orally twice daily after at least 6 months of treatment for DVT or PE.
Renal Impairment: Prevention of VTE: Elective Hip or Knee Replacement Surgery: No dose adjustment is necessary in patients with mild, moderate or severe (creatinine clearance 15-29 mL/min) renal impairment (see Pharmacology: Pharmacokinetics: Renal impairment under Actions). Because there is limited clinical experience in patients with creatinine clearance <15 mL/min and no data in patients undergoing dialysis, apixaban is not recommended in these patients (see Renal Impairment: Prevention of VTE: Elective Hip or Knee Replacement Surgery under Precautions and Pharmacology: Pharmacokinetics: Renal Impairment under Actions).
Prevention of Stroke and Systemic Embolism: NVAF: No dose adjustment is recommended in patients with creatinine clearance 15 to 29 mL/min, except as described in Prevention of Stroke and Systemic Embolism: NVAF under Dosage & Administration. Because there is no clinical experience in patients with creatinine clearance <15 mL/min, a dosing recommendation cannot be provided.
There are no data in patients undergoing dialysis, therefore, ELIQUIS is not recommended in these patients (see Pharmacology: Pharmacokinetics: Renal Impairment under Actions).
Treatment of VTE: No dose adjustment is necessary in patients with mild, moderate, or severe (creatinine clearance 15-29 mL/min) renal impairment (see Pharmacology: Pharmacokinetics: Renal impairment under Actions). Because there is limited clinical experience in patients with creatinine clearance <15 mL/min and no data in patients undergoing dialysis, apixaban is not recommended in these patients (see Pharmacology: Pharmacokinetics: Renal Impairment under Actions).
Hepatic Impairment: ELIQUIS may be used with caution in patients with mild or moderate hepatic impairment (Child Pugh A or B). No dose adjustment is required in patients with mild or moderate hepatic impairment (see Hepatic Impairment under Precautions and Pharmacology: Pharmacokinetics: Hepatic Impairment under Actions).
ELIQUIS is not recommended in patients with severe hepatic impairment (see Hepatic Impairment under Precautions and Pharmacology: Pharmacokinetics: Hepatic Impairment under Actions).
Body Weight: Prevention of VTE: Elective Hip or Knee Replacement Surgery: No dose adjustment required (see Pharmacology: Pharmacokinetics under Actions).
Prevention of Stroke and Systemic Embolism: NVAF: See Prevention of stroke and systemic embolism: NVAF under Dosage & Administration.
Treatment of VTE: No dose adjustment required (see Pharmacology: Pharmacokinetics under Actions).
Gender: No dose adjustment required (see Pharmacology: Pharmacokinetics under Actions).
Pediatric and Adolescent: The efficacy and safety of ELIQUIS in children below age 18 have not been established. No data are available.
Elderly: Prevention of VTE: Elective hip or knee replacement surgery: No dose adjustment required (see Pharmacology: Pharmacokinetics under Actions).
Prevention of Stroke and Systemic Embolism: NVAF: See Prevention of stroke and systemic embolism: NVAF under Dosage & Administration.
Treatment of VTE: No dose adjustment required (see Pharmacology: Pharmacokinetics under Actions).
Converting From or to Parenteral Anticoagulants: In general, switching treatment from parenteral anticoagulants to ELIQUIS (and vice versa) can be done at the next scheduled dose.
Converting From or to Warfarin or Other vitamin K Antagonists (VKA): When converting patients from warfarin or other VKA therapy to ELIQUIS, discontinue warfarin or other VKA therapy and start ELIQUIS when the international normalized ratio (INR) is below 2.0.
When converting from ELIQUIS to warfarin or other VKA therapy, continue ELIQUIS for 48 hours after the first dose of warfarin or other VKA therapy.
Surgery and Invasive Procedures: ELIQUIS should be discontinued at least 48 hours prior to elective surgery or invasive procedures with a moderate or high risk of unacceptable or clinically significant bleeding. ELIQUIS should be discontinued at least 24 hours prior to elective surgery or invasive procedures with a low risk of bleeding or where the bleeding would be non-critical in location and easily controlled. If surgery or invasive procedures cannot be delayed, exercise appropriate caution taking into consideration an increased risk of bleeding. This risk of bleeding should be weighed against the urgency of intervention. In non-valvular atrial fibrillation patients, bridging anticoagulation during the 24 to 48 hours after stopping ELIQUIS and prior to the intervention is not generally required.
ELIQUIS should be restarted after the surgical or other procedures as soon as adequate hemostasis has been established.
ELIQUIS can be initiated or continued in NVAF patients who may require cardioversion.
For patients not previously treated with anticoagulants, at least 5 doses of ELIQUIS 5 mg twice daily [2.5 mg twice daily in patients who qualify for a dose reduction (see Dosage & Administration)] should be given before cardioversion to ensure adequate anticoagulation (see Precautions).
If cardioversion is required before 5 doses of ELIQUIS can be administered, a 10 mg loading dose should be given, followed by 5 mg twice daily. The dosing regimen should be reduced to a 5 mg loading dose followed by 2.5 mg twice daily if the patient meets the criteria for dose reduction (see Dosage & Administration). The administration of the loading dose should be given at least 2 hours before cardioversion (see Precautions).
Confirmation should be sought prior to cardioversion that the patient has taken ELIQUIS as prescribed. Decisions on initiation and duration of treatment should take established guideline recommendations for anticoagulant treatment in patients undergoing cardioversion into account.
Administration options: For patients who are unable to swallow whole tablets, ELIQUIS tablets may be crushed and suspended in water, 5% dextrose in water (D5W), or apple juice, or mixed with apple sauce and promptly administered orally (see Precautions). Alternatively, ELIQUIS tablets may be crushed and suspended in 60 mL of water or D5W and promptly delivered through a nasogastric tube (see Precautions).
Crushed ELIQUIS tablets are stable in water, D5W, apple juice, and apple sauce for up to 4 hours.
Mode of Administration: Oral administration.