Known hypersensitivity to the active substance or to any of the excipients; known or suspected progestogen dependent neoplasms (e.g. meningioma); undiagnosed vaginal bleeding. Treatment for luteal support as part of an Assisted Reproductive Technology (ART) treatment must be discontinued upon diagnosis of abortion/miscarriage. Contraindications for the use of estrogens when used in combination with dydrogesterone.