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Pharmacology: Pharmacodynamics: Itopride is a substituted benzamide that has been used for prokinetic agent and antiemetic agent. Itopride acts as the dopamine receptor (D2 subtype) antagonist. It also acts as acetylcholine esterase inhibitor leading to the elevation of acetylcholine level and gastrointestinal motility.
Pharmacokinetics: Absorption: Itopride is absorbed rapidly by oral administration. The peak plasma concentration occurred within 0.50-0.66 hour. The bioavailability is calculated to be 60%.
Distribution: 96% of Itopride is bound to plasma proteins.
Metabolism: Itopride undergoes N-oxidation via flavine monooxygenase enzymes (FMO1 and FMO3).
Elimination: Itopride is excreted into urine as main metabolite and unchanged drug, in amount of 68% and 4% respectively. The half-life elimination of Itopride is 5.7±0.3 hours.
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