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Hypersensitivity to estradiol hemihydrate or to any of the excipients of Divigel.
Known or suspected estrogen-dependent malignant tumours (eg, endometrial cancer); undiagnosed genital bleeding; untreated endometrial hyperplasia; previous or current venous thromboembolism [deep venous thrombosis (DVT), pulmonary embolism]; known thrombophilic disorders [eg, protein C, protein S, or antithrombin deficiency (see Precautions); active or recent arterial thromboembolic disease (eg, angina, myocardial infarction); acute liver disease or a history of liver disease as long as liver function tests have failed to return to normal; porphyria; known, past or suspected breast cancer.
