Ditoin Dosage & Drug Information

Indications/Uses

Cap: Psychomotor epilepsy, migraine & trigeminal neuralgia. Inj: Control of status epilepticus (grand mal type).

Dosage/Direction for Use

Cap Adult 100 mg tid, increase to 200 mg tid if necessary. Childn 30 mg bid. Inj 100-250 mg by slow IV, then 100-150 mg 30 min later. Max IV rate: 50 mg/min.

Administration

Should be taken with food: When administering to patients on nasogastric or other enteral feeds, do not administer feeds 2 hr before or after a dose. Be consistent throughout therapy in relation to feed times. Swallow cap whole, do not open/chew/crush. Do not switch dosage forms/brands w/o prior consideration.

Contraindications

Pregnancy.

Special Precautions

Not for seizures due to hypoglycemia. Impaired liver function, slow acetylators. SA node depression & AV block (on IV administration). Avoid abrupt w/drawal; lactation. Elderly & gravely ill patients.

Adverse Reactions

Nystagmus, ataxia, slurred speech, confusion, dizziness, gingival hyperplasia, hirsutism, morbilliform rash, rickets, osteomalacia, lupus erythematosus syndrome, leukopenia, thrombocytopenia, pancytopenia, granulocytopenia. Inj: CV collapse & CNS depression. Hypotension (if administered rapidly). Cardiac arrhythmia, ventricular fibrillation & ventricular arrest.

View ADR Reporting Link

Drug Interactions

Enhanced metabolism by barbiturates. Inhibited metabolism by chloramphenicol, coumarin anticoagulants, disulfiram, phenylbutazone, phenyramidol, INH, sulfaphenazole, sulthiame, valproic acid, cimetidine & sulfonamides.

MIMS Class

Anticonvulsants

ATC Classification

N03AB02 - phenytoin ; Belongs to the class of hydantoin derivatives antiepileptics.

Thai FDA Category

D

Presentation/Packing

Form

Ditoin cap 100 mg

Packing/Price

1000's

Form

Ditoin infusion 50 mg/mL

Packing/Price

5 mL x 10 × 1's

Ditoin

phenytoin

Manufacturer:

Atlantic Lab

Distributor:

Atlantic Pharma