DiffCof Dual Action Chesty Cough Syrup Special Precautions

Patients being treated with DiffCof Dual Action Chesty Cough Syrup should be notified of an expected increase in the flow of secretions.
In acute respiratory indications, medical advice should be sought if symptoms do not improve rapidly or worsen during course of therapy.
There have been very rare reports of severe skin lesions such as Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis (TEN) in temporal association with the administration of mucolytic substances such as bromhexine. Mostly, these could be explained by the severity of the patient's underlying disease and/or concomitant medication. In addition, during the early phase of a Stevens-Johnson syndrome or TEN a patient can first experience non-specific influenza-like prodromes like e.g. fever, aching body, rhinitis, cough and sore throat. Misled by these non-specific influenza-like prodromes it is possible that a symptomatic treatment is started with a cough and cold medication. Therefore, if new skin or mucosal lesions occur, medical advice should be sought immediately and treatment with bromhexine should be discontinued as a precaution.
This product contains 7,500 mg of 70% Sorbitol Solution per maximum recommended daily dose for adult. Patients with the rare hereditary condition of fructose intolerance should not take this medicine. This product contains sorbitol, which may have a laxative effect or can cause diarrhoea in some people.
Urinary calculi have been reported in patients consuming large quantities of the products containing guaifenesin. Small quantities of ephedrine were also present in the stones of one of several patients who had ingested preparations containing a combination of guaifenesin and ephedrine.
Risk in Specific Populations: When using preparations containing guaifenesin, caution should be exercised in the presence of severe renal or severe hepatic impairment as there have been no specific studies of guaifenesin in subjects with renal or hepatic impairment.
Effects on the ability to drive and use machines: No studies on the effects on the ability to drive and use machines have been performed with DiffCof Dual Action Chesty Cough Syrup.