Dayvus 50 Dosage/Direction for Use

Adult: Vildagliptin may take with or without food.
Monotherapy or combination (dual therapy) with metformin or thiazolidinedione or insulin (with or without metformin): 50 mg orally once daily in the morning or twice daily in the morning and evening.
Triple therapy in combination with a sulfonylurea and metformin: 50 mg orally twice daily in the morning and evening.
When using dual combination with a sulfonylurea: 50 mg once daily in morning.
If tighter glycemic control is required on the top of the maximum recommended daily dose of vildagliptin, the addition of other antidiabetic drugs such as metformin, SU, TZD or insulin may be considered.
Dose adjustment: Renal impairment: mild (CrCl ≥50 mL/min): no dose adjustment necessary.
Renal impairment: moderate to severe or ESRD: Initial 50 mg orally once daily (maximum 50 mg per day).
Hepatic impairment including patients with a pre-treatment ALT or AST >2.5x the upper limit of normal: use not recommended.
Geriatric (65 years or older): no dose adjustment is necessary.