Darflox Drug Interactions

Darflox should not be co-administered with the following drugs: Fenbufen, Flurbiprofen axetil, Flurbiprofen: Signs, Symptoms and Treatment: Convulsions may occur. If any symptom is observed, appropriate measures eg, discontinuation of both drugs should be taken.
Mechanism and Risk Factors: It is considered that the inhibitory action of prulifloxacin against GABA_A receptor binding may be enhanced by co-administration and as a result convulsions may be induced.
Darflox should be administered with care when co-administered with the following drugs: Theophylline, Aminophylline, etc: Signs, Symptoms and Treatment: Blood concentration of theophylline may be increased and effects of theophylline may be enhanced. In case of co-administration, appropriate measures eg, reducing the dose of theophylline should be taken.
Mechanism and Risk Factors: It is considered that theophylline metabolism in the liver is inhibited by slight inhibitory action of prulifloxacin against CYP1A and blood concentration of theophylline is increased as a result. Careful attention should be particularly paid to elderly patients and patients with renal disorder.
Nonsteroidal Anti-Inflammatory Drugs of Phenylacetic Acid Derivatives (Fenbufen is contraindicated for co-administration): Diclofenac, etc; Propionic Acid Derivatives (Flurbiprofen axetil and flurbiprofen are contraindicated for co-administration): Ketoprofen, etc: Signs, Symptoms and Treatment: Convulsions may occur. If any symptom is observed, appropriate measures eg, discontinuation of both drugs should be taken.
Mechanism and Risk Factors: It is considered that the inhibitory action of prulifloxacin against GABA_A receptor binding may be enhanced by co-administration and convulsions may be induced as a result. Careful attention should be particularly paid to patients with convulsive disorders eg, epilepsy, patients with a history of such disorders, elderly and patients with renal disorder.
Antacids Containing Aluminum or Magnesium, Iron Preparations, Preparations Containing Calcium: Signs, Symptoms and Treatment: The effect of prulifloxacin may be reduced. Careful attention should be paid to administration of these drugs. For example, these drugs should be administered at intervals of >2 hrs after administration of prulifloxacin.
Mechanism and Risk Factors: It is considered that the absorption of prulifloxacin is inhibited by the chelate formation with metal ion of these drugs.
H₂-Receptor Antagonist eg, Cimetidine, etc; Proton Pump Inhibitor eg, Omeprazole, etc: Signs, Symptoms and Treatment: The effect of prulifloxacin may be reduced.
Mechanism and Risk Factors: It is considered that the absorption of prulifloxacin is decreased, as a result of the elevated pH in the stomach by these drugs and the decreased solubility of Darflox.