CRESTOR is contraindicated: in patients with hypersensitivity to rosuvastatin or to any of the excipients; in patients with active liver disease including unexplained, persistent elevations of serum transaminases and any serum transaminase elevation exceeding 3x the upper limit of normal (ULN); in patients with severe renal impairment (creatinine clearance <30 ml/min); in patients with myopathy; in patients receiving concomitant cyclosporin.