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Pregnancy: Category B.
In clinical trials, use of vaginally applied Clotrimazole in pregnant women in their second and third trimester has not been associated with ill effects. However, one study did find a significant increase in the risk spontaneous abortions (SABs) with first trimester vaginitis treatment. A later study speculated that this effect might have been due to inhibition of the critical enzyme aromatase. Until there are more data regarding this possible association, the best course is to avoid to use of Clotrimazole for vaginitis treatment in the first trimester.
Lactation: It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Clotrimazole is used by a nursing women.
