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Hypersensitivity to clopidogrel, ASA and NSAIDs or to any of the excipients of CoPlavix. Severe hepatic impairment; active pathological bleeding eg, peptic ulcer or intracranial haemorrhage.
In addition, due to the presence of ASA, CoPlavix is also contraindicated in patients with syndrome of asthma, rhinitis and nasal polyps and preexisting mastocytosis, in whom the use of ASA may induce severe hypersensitivity reactions (including circulatory shock with flushing, hypotension, tachycardia and vomiting); severe renal impairment [creatinine clearance (CrCl) <30 mL/min); 3rd trimester of pregnancy (see Use in pregnancy under Precautions).
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