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Prior to initiation of therapy with amoxicillin and clavulanate potassium, careful inquiry should be made concerning previous hypersensitivity reactions to penicillins, cephalosporins, or other drugs.
Because a high percentage of patients with infectious mononucleosis have developed rash during therapy with amoxicillin and clavulanate potassium should not be used in patients with disease.
Renal, hepatic and hematologic function should be evaluated periodically during prolonged therapy with amoxicillin and clavulanate potassium. Because Clostridium difficile-associated diarrhea and colitis has been reported with the use of anti-infective agents including amoxicillin and clavulanate potassium, it should be considered in the differential diagnosis of patients who develop diarrhea during amoxicillin and clavulanate potassium therapy.
Susp: Severely impaired liver or renal function. Newborn & infants.
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