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Concomitant use of probenecid and Cefotaxime may increase the level of Cefotaxime in blood circulation as probenecid decreases an excretion at glomerular filtration.
Concomitant use of aminoglycosides and Cefotaxime may be additive against some strains of Pseudomonas aeruginosa and Serratia marcescens and may increase the risk of nephrotoxicity. Renal function should be carefully monitored, especially if therapy is prolonged or if high aminoglycoside dosage is used.
Cefotaxime may interfere with laboratory tests e.g. Positive direct antiglobulin test (Coombs' test), urinary glucose determinations using cupric sulfate (Benedict's reagent, Clinitest) and falsely elevated serum or urine creatinine value when the Jaffe reaction used.
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