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Capsule: Symptoms: Neither accidental nor intentional overdosage with ursodeoxycholic acid has been reported. The most likely manifestation of severe overdose with ursodeoxycholic acid would likely be diarrhea.
Treatment: Should be treated symptomatically.
Oral suspension: Diarrhoea may occur in cases of overdose. In general, other symptoms of overdose are unlikely, because the absorption of UDCA decreases with increasing dose and therefore more is excreted with the faeces.
No specific countermeasures are necessary and the consequences of diarrhoea should be treated symptomatically with restoration of fluid and electrolyte balance.
Additional information on special populations: Long-term, high-dose UDCA therapy (28-30 mg/kg/day) in patients with primary sclerosing cholangitis (off-label use) was, associated with higher rates of serious adverse events.
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