Cellufresh Mechanism of Action

Pharmacology: Pharmacodynamics: No clinical pharmacology studies were performed with Cellufresh.
CMC has no pharmacological receptor-mediated properties. The mode of action of CMC is based on its physical properties which provide a lubricant effect and prolonged residence time in the eye. CMC increases tear viscosity and has pseudo-elastic (i.e. shear thinning) properties. Since CMC is an ionic polymer containing carboxyl and hydroxyl groups, its chemical structure is similar to mucin in the tear film, and thus it has mucoadhesive properties. These properties promote prolonged residence times in the eye which alleviate the symptoms of tear deficiency. In the U.S., carboxymethylcellulose is described as an ophthalmic demulcent; an agent which is applied topically to the eye to protect and lubricate mucous membrane surfaces and relieve dryness and irritation.
Pharmacokinetics: No ocular pharmacokinetic studies have been performed. Since carboxymethylcellulose sodium is pharmacologically inert and not absorbed systemically, it is not expected that patient safety concerns will arise from the topical administration of Cellufresh.