Cardepine Drug Interactions

SR cap: Being a vasodilator, CARDEPINE may potentiate the effect of hypotensive agents No drug interaction has been reported with the use of parenteral Nicardipine.
Inj: Beta-blockers (e.g., propranolol): Beta-blockers result in an excessive decrease in BP and a reduction in cardiac function in patients with congestive heart failure. Reduce dosage or discontinue use of either drug when necessary.
Cimetidine: Cimetidine increases nicardipine plasma levels. Patients receiving the two drugs concomitantly should be carefully monitored.
Digoxin: Nicardipine may increase plasma levels of digitalis preparations. Evaluate digoxin levels when concomitant therapy with nicardipine IV is initiated.
Fentanyl Anesthesia: Concomitant use of fentanyl anesthesia with a calcium channel blocker has been reported to cause hypotension. Although such interactions were not seen in studies with nicardipine IV, an increased volume of circulating fluids might be necessary in the occurrence of such interactions.
Ciclosporin: Concomitant administration increases ciclosporin plasma levels. Ciclosporin dosage should therefore be reduced accordingly in patients treated with nicardipine.
Other antihypertensive agents: Monitor patients to identify and treat promptly any undesirable effects from concomitant administration.
In vitro Interaction: No changes in plasma protein binding of nicardipine were observed when furosemide, propranolol, dipyridamole, warfarin, quinidine, or naproxen were added to human plasma in vitro.