Cal-Os/Cal-Os Plus D/Cal-Os Chew

Ca deficiencies eg, postmenopausal period, osteoporosis in geriatrics, rickets & osteomalacia, acute & chronic hypoparathyroidism, hypocalcemia. Cal-Os Plus D/Cal-Os Chew Treatment & prevention of osteoporosis. Prevention of Ca deficiency or Ca supplement in adult, childn ≥6 yr, elderly ≥50 yr, post menopause, vit D deficiency, pregnancy, lactation.

Cal-Os 350 mg cap 2 cap bid to tid, 835 mg 1 cap bid to tid. FC tab 1,000 & 1,250 mg 1 tab bid, 1,500 mg 1 tab once daily to bid. Cal-Os Plus D tab 1-2 tab daily. Cal-Os Chew chewable tab Ca deficiency 2-3 tab bid-tid. Prevention of Ca deficiency or Ca supplement Adult, adolescent & childn 6-12 yr 2 tab bid.

Should be taken with food.

Hypersensitivity. Hypercalcemia caused by sarcoidosis, hyperparathyroidism, hypervitaminosis D, certain cancers (cancer-induced hypercalcemia) eg, lung & breast cancer, & multiple myeloma.

Not to exceed total amount of Ca intake of 1,500 mg/day. Gastric hypersecretion & acid rebound. Hypercalcemia; milk-alkaline syndrome. Impaired absorption in achlorhydria. Chronic hypercalcemia resulting to vascular calcification & other soft-tissue calcification. Increased risk of cardiac arrhythmias & seizures. Patients w/ history of kidney stones. Avoid excessive dose or prolonged use. Monitor serum Ca conc wkly in patients receiving large dose of Ca carbonate. Reduced absorption w/ food. Chronic renal failure. Hepatic impairment. Pregnancy & lactation. Elderly.

Constipation, flatulence, swollen abdomen or bloating, nausea, loss of appetite; gastric hypersecretion, acid rebound.

Reduced absorption of bisphosphonates (eg, alendronate, etidronate, ibandronate, risedronate); oral Fe prep. Synergistic effect w/ cardiac glycosides. Decreased absorption of levothyroxine. Reduced oral bioavailability of fluoroquinolone. Complex formation w/ tetracycline. Cal-Os Plus D Decreased intestinal absorption of vit D analogs w/ cholestyramine or colestipol HCl. Decreased GI absorption of vit D analogs w/ orlistat. May interfere w/ intestinal absorption of vit D analogs w/ mineral oil. Altered serum calcifediol conc w/ cytochrome P450 enzyme inhibitors eg, atazanavir, clarithromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, voriconazole. Decreased plasma conc w/ anticonvulsants eg, carbamazepine, phenobarb, phenytoin & other drugs that induce hepatic microsomal hydroxylation. Hypercalcemia w/ thiazide diuretics. Counteracted effects of vit D analogs w/ corticosteroids. Cardiac arrhythmias w/ cardiac glycosides.

Calcium/with Vitamins

A12AA04 - calcium carbonate ; Belongs to the class of calcium-containing preparations. Used as dietary supplements.
A12AX - Calcium, combinations with vitamin D and/or other drugs ; Used as dietary supplements.

NDD