The most common adverse effects of salbutamol include peripheral vasodilatation and as a result small increase in heart rate, palpitations and tremor. Other adverse effects of salbutamol include headache, hypersensitivity reactions (angioedema, urticaria, hypotension and collapse), bronchospasm (see Precautions), cough, irritation of mouth and throat which may be prevented by rinsing the mouth after inhalation, hypokalaemia, muscle cramps, hyperactivity, restlessness, dizziness and cardiac arrhythmias including atrial fibrillation, supraventricular tachycardia and extrasystoles, myocardial ischaemia (see Precautions).
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