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Pregnancy: The safety of use during human pregnancy has not been established. In animal studies, brimonidine tartrate did not cause any teratogenic effects. In rabbits, brimonidine tartrate, at plasma levels higher than are achieved during therapy in humans, has been shown to cause increased preimplantation loss and postnatal growth reduction. Brizagan should be used during pregnancy only if the potential benefit to the mother outweighs the potential risk to the foetus. To reduce the systemic absorption, see Dosage & Administration.
Breast-feeding: It is not known if brimonidine is excreted in human milk. The compound is excreted in the milk of the lactating rat. Brizagan should not be used by women nursing infants.
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