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The Povidone-iodine complex is effective at pH values of between 2.0 and 7.0. It has to be expected that the complex will react with protein and other unsaturated organic compounds, leading to impairment of its effectiveness.
The concomitant use of wound-treatment preparations containing enzymatic components leads to a weakening of the effects of both substances. Products containing mercury (see Contraindications), silver, hydrogen peroxide, and taurolidine may interact with povidone-iodine and cause mutual reduction of effects.
Povidone-iodine products when used before or after application of octenidine may lead to transient dark discolourations at the application site.
Due to the oxidative effect of povidone-iodine preparations various diagnostic agents can show false-positive lab results (e.g., tests with toluidine or gum guaiac for the determination of hemoglobin or glucose in the stool or the urine).
Absorption of iodine from povidone-iodine products may lower the iodine uptake of the thyroid. This can lead to interference with various investigations [(thyroid scintigraphy, determination of protein-bound iodine (PBI), radioiodine diagnostics)] and can make a planned treatment of the thyroid with iodine (radioiodine therapy) impossible. After the end of the treatment, 4 weeks should be allowed before anew scintigram is carried out (see Contraindications).
