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Overdose: Information on acute overdosage with cilostazol in humans is limited. The signs and symptoms of an acute overdose can be anticipated to be those of excessive pharmacologic effect, including the following: severe headache, diarrhea, hypotension, tachycardia, and possibly cardiac arrhythmias.
The oral median lethal dose of cilostazol is greater than 5 g/kg in mice and rats and greater than 2 g/kg in dogs.
Treatment: Carefully observe the patient and provide supportive treatment. Since cilostazol is highly protein bound, it is unlikely that it can be efficiently removed by hemodialysis or peritoneal dialysis.
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