Beclomet Nasal Aqua Mechanism of Action

Beclomethasone dipropionate is a synthetic steroid derivative. It has a potent anti-inflammatory and antioedemic effect on the mucous membrane when administered into the nose. Beclomethasone acts topically and the absorption from the nasal mucous membrane is slight. Thus, it acts in the superficial layers of the tissue, and with the recommended dosage, it is devoid of systemic effects.
Beclomethasone dipropionate is absorbed from the nasal mucosa. Part of the nasally administered dose of beclomethasone can pass the nose with inhaled air and is retained in the pharynx where it may be swallowed. This fraction undergoes a rapid first-pass in the liver to inactivate metabolites. The drug that is absorbed from the nasal mucosa avoids this metabolism, but is ultimately metabolized in the liver.
Beclomethasone dipropionate is metabolized to beclomethasone monopropionate and free beclomethasone, and metabolites are mainly excreted in the faeces.
As an aqueous suspension, Beclomet Nasal Aqua is an alternative to nasal aerosols, especially for patients suffering from dryness of nose caused by nasal aerosols.