Atorvastatin is contraindicated in patients: with hypersensitivity to the active substance or to any of the excipients; with active liver disease or unexplained persistent elevations of serum transaminases exceeding 3 times the upper limit of normal; treated with hepatitis C antivirals glecaprevir/pibrentasvir; during pregnancy, while breast-feeding and in women of child-bearing potential not using appropriate contraceptive measures (see Use in Pregnancy & Lactation).