Patients with known hypersensitivity to any component of this product.
Patients with active peptic ulceration or gastro-intestinal (GI) bleeding.
Patients with severe hepatic dysfunction (Child-Pugh score >9).
Patients with estimated creatinine clearance <30 mL/min.
Patients who have developed signs of asthma, acute rhinitis, nasal polyps, angioneurotic oedema or urticaria following the administration of aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs).
Children under 16 years of age.
Patients with inflammatory bowel disease.
Patients with congestive heart failure (NYHA II-IV).
Patients with hypertension whose blood pressure has not been adequately controlled.
Patients with established ischemic heart disease, peripheral arterial disease and/or cerebrovascular disease (including patients who have recently undergone coronary artery bypass graft surgery or angioplasty).
Use in Pregnancy & Lactation: Pregnancy and lactation.
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