OA 30 mg or 60 mg daily. Acute & chronic RA, ankylosing spondylitis 90 mg once daily. Acute gouty arthritis 120 mg once daily. Max duration for acute symptomatic period: 8 days. Relief of chronic musculoskeletal pain, including chronic low back pain 60 mg once daily. Primary dysmenorrhea 120 mg once daily. Max duration of treatment: 8 days. Relief of acute pain associated w/ dental surgery 90 mg once daily. Max duration of treatment: 3 days. Post-op gynecological surgery pain 90 mg once daily. Max duration of treatment: 5 days.
View Arcona overdosage for action to be taken in the event of an overdose.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Active peptic ulceration or GI bleeding. Severe hepatic dysfunction (Child-Pugh score >9). Estimated CrCl <30 mL/min. Patients who develop signs of asthma, acute rhinitis, nasal polyps angioneurotic oedema or urticaria following administration of aspirin or other NSAIDs. Inflammatory bowel disease; CHF (NYHA II-IV); inadequately controlled BP; ischemic heart disease, peripheral arterial disease &/or cerebrovascular disease (including patients who have recently undergone CABG surgery or angioplasty). Pregnancy & lactation. Childn <16 yr.
Contraindicated in known hypersensitivity, pregnancy & lactation, CABG surgery patients, CV or cerebrovascular disease, uncontrolled HTN, MI or CHF (NYHA II-IV), history of ischemic heart disease or history of paralysis from cerebrovascular disease. Patients w/ risk factors for CV events eg, HTN, hyperlipidemia, DM, smoking, elderly. Liver & kidney disorders.
Concomitant use w/ anticoagulants eg, warfarin may cause bleeding. GI bleeding may occur w/ NSAIDs eg, ibuprofen, diclofenac, naproxen. Digoxin. May increase plasma lithium levels.
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