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For the treatment of systemic fungal infections, AMPHOTERICIN-B is given by slow intravenous infusion over a period of 2 - 6 hours. The recommended concentration for intravenous infusion is 0.1 mg/ml (1 mg/10 ml).
The initial daily dose is 0.25 mg/kg of body weight given over 2 - 6 hours.
In patients with good cardiopulmonary function and well toleration without severe reaction, the daily dose should be initiated with 0.3 mg/kg of body weight.
In patients with impaired cardiopulmonary function or severe reaction, it should be initiated with smaller daily doses: 5-10 mg.
Depending on the patient's status, doses may gradually be increased by 5 - 10 mg per day to final dosage of 0.5 to 0.7 mg/kg of body weight per day.
