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Postural hypotension may occur with potential for syncope, especially in patients with a history of symptomatic hypotension, who have had a hypotensive response to other medications, or who are receiving concurrent antihypertensive medications or nitrates.
Risk of new or worsening angina pectoris; discontinue.
Use caution in patients with acquired or congenital QT prolongation or in those taking other medication known to prolong the QT interval.
Use with other alpha-blockers is not recommended.
Use with caution in patients with mild hepatic impairment.
Intraoperative floppy iris syndrome has been reported during cataract surgery; modification to surgical technique may be necessary.
Use with caution in patients with severe renal impairment (CrCl <30 mL/minute).
Rule out carcinoma of the prostate prior to initiating therapy for benign prostatic hypertrophy; both conditions may present with the same symptoms.
Priapism has been reported and may lead to permanent impotence if not treated immediately.
Effects on ability to drive and use machines: There are no data available on the effect on driving vehicles. Particular caution is required when driving vehicles or using machines due to the risks of postural hypotension, vertigo, dizzy sensations, asthenia, visual disturbances, especially at the start of treatment with alfuzosin.
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