Doxorubicin hydrochloride is contraindicated in patients with: Severe myocardial insufficiency; recent (occurring within the past 4-6 weeks) myocardial infarction; severe persistent drug-induced myelosuppression, severe hepatic impairment (defined as Child Pugh Class C or serum bilirubin level greater than 5 mg/dL); severe hypersensitivity reaction to doxorubicin hydrochloride including anaphylaxis; any component of the formulation, or to other anthracyclines or anthracenediones.
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