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In general, overdosage with Addamel N is extremely unlikely as the quantity of trace elements per ampoule lies well below known toxic levels of administration.
Chronic overdosage may very rarely occur secondary to an unsuspected idiosyncratic deficiency in metabolism or excretion of a trace element. In this case, signs eg, nail dystrophy and insidious onset of symptoms secondary to hematological changes or tissue deposition, may be observed. Diagnosis would be confirmed by biochemical or hematological tests and treatment with Addamel N should be withdrawn.
