Herpes Simplex Infections: Mucosal and Cutaneous Herpes Simplex (HSV-1 and HSV-2) Infections in Immunocompromised Patients: 5 mg/kg infused at a constant rate over 1 hour, every 8 hours (15 mg/kg/day) for 7 days in adult patients with normal renal function. In pediatric patients under 12 years of age, more accurate dosing can be attained by infusion 250 mg/m2 at a constant rate over 1 hour, every 8 hour, every 8 hour (750 mg/m2 day) for 7 days.
Herpes Simplex Encephalitis: 10 mg/kg infused at a constant rate over at least 1 hour, every 8 hours for 10 days. In pediatric patients between 6 months and 12 years of age more accurate dosing is achieved by infusion 500 mg/m2, at constant rate over at least 1 hour, every 8 hours for 10 days.
Varicella Zoster Infections: Zoster in Immunocompromised Patients: 10 mg/kg infused at a constant rate over 1 hour, every 8 hours, for 7 days in adult patients with normal renal function. In pediatrics under 12 years of age, plasma concentrations are attained by infusion 500 mg/m2 at a constant rate over at least 1 hour, every 8 hours for 7 days. Obese patients should be dosed at 10 mg/kg (Ideal Body Weight). A maximum dose eq. to 500 mg/m2 every 8 hours should not be exceeded for any patient.
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