Phenobarbitone and alcohol potentiate hepatotoxicity of paracetamol. Bioavailability of paracetamol is decreased in epileptic patients on anticonvulsants possibly because of first pass metabolism secondary to enzyme induction. Despiramine may delay and reduce the peak concentration of paracetamol in blood. There may be an increased risk of liver damage when doxorubicin and paracetamol are used together. Paracetamol has also been reported to increase the half-life of chloramphenicol. Orphenadrine citrate has been shown to induce enzymatic systems involving the metabolism of aminopyrine, steroidal contraceptives, griseofulvin, hexobarbital, and phenylbutazone. Orphenadrine will potentiate other anticholinergic agents.