Safety and tolerance of Domar in therapeutic dosage (10 mg per day) is good. At the start of treatment and when large doses are administered one can occasionally see a more marked sedative action or slight somnolence. These effects disappear spontaneously during treatment or on adjusting the dosage. When administering benzodiazepines one has observed, although rarely, confusion, ataxia, skin rashes, digestive disturbance. Rarely one may encounter bone marrow depression and liver damage, these being usually reversible.