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Pharmacology: Pharmacodynamics: Miconazole is an imidazole antifungal agent which interferes with ergosterol synthesis and therefore alters the permeability of the cell membrane of sensitive fungi.
Pharmacokinetics: Miconazole has shown fungistatic activity, in vitro, against a number of fungi causing systemic mycoses such as Coccidioides immitis, Histoplasma capsulatum, Blastomyces dermatitides and Cryptococcus neoformans. Miconazole appears to act on the fungal cell wall and membranes inducing permeability changes which alter the ionic macromo lecular composition of the effected cells. At high concentrations, Miconazole has shown fungicidal activity against various organisms. Miconazole readily penetrates the stratum corneum into the blood. Absorption is no more than 1.3% from the vagina.
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