Zoresan Warnings

Serious rashes may occur in association with Zonisamide (Zoresan) therapy, including cases of Stevens-Johnson syndrome.
Heat stroke and dehydration.
Preventing overheating and dehydration in children.
Zonisamide (Zoresan) can cause children to sweat less and overheat and if the child is not treated this can lead to brain damage and death. Children are most at risk especially in hot weather.
When a child is taking Zonisamide (Zoresan): The child should stay cool especially in hot weather; The child must avoid heavy exercise especially when the weather is hot; The child must drink plenty of cold water; The child must not take any of these medicines: carbonic anhydrase inhibitors (like topiramate and acetazolamide), and anticholinergic agents (like clomipramine, hydroxyzine, diphenhydramine, haloperidol, imipramine and oxybutynin.
If any of the following occur, the child needs urgent medical.
Attention: The skin feels very hot with little or no sweating, or the child becomes confused or has muscle cramps, or the child's heartbeat or breathing become rapid.
Take the child to a cool, shaded place.
Keep the child's skin cool with water.
Give the child cold water to drink.