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Drug interactions may be the result of altered pharmacokinetics or pharmacodynamics due to one of the following drugs involved.
Aminoglycosides: The caution should be taken during the co-administration of bisphosphonates and aminoglycosides, since these agents may have an additive effect to lower serum calcium level for prolonged periods.
Loop Diuretics: Caution should also be exercised when Zoledronic Acid is used in combination with loop diuretics due to an increased risk of hypocalcemia.
Nephrotoxic Drugs: Caution should be taken when Zoledronic Acid is used with other potentially nephrotoxic drugs.
Thalidomide: The co-administration of Zoledronic Acid with thalidomide may increase the risk of renal dysfunction in multiple myeloma patients.
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