Zofran Caution For Usage

Incompatibilities: Compatibility with IV fluids: Compatibility studies have shown that unpreserved ondansetron injection is stable for seven days at room temperature (below 25°C) under fluorescent lighting or in a refrigerator with the following IV infusion fluids: Sodium Chloride IV Infusion BP 0.9% w/v, Glucose IV Infusion BP 5% w/v, Mannitol IV Infusion BP 10% w/v, Ringers IV Infusion, Potassium Chloride 0.3% w/v and Sodium Chloride 0.9% w/v IV Infusion BP, Potassium Chloride 0.3% w/v and Glucose 5% w/v IV Infusion BP.
Compatibility with other drugs: Ondansetron may be administered by IV infusion at 1 mg/h, from an infusion bag or syringe pump. The following drugs may be administered via the Y-site of the ondansetron giving set for ondansetron concentrations of 16 to 160 micrograms/mL (e.g. 8 mg/500 mL and 8 mg/50 mL respectively): See Table 6.

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Instruction for Use/Handling: Injection: Ondansetron (Zofran) injection should not be administered in the same syringe or infusion as any other medication (see INCOMPATIBILITIES as previously mentioned).
Ondansetron (Zofran) injection should only be mixed with those infusion solutions which are recommended (see INCOMPATIBILITIES as previously mentioned).
Solution for Injection: The solution for injection is unpreserved, should only be used once and injected or diluted immediately after opening. Any remaining solution should be discarded. Ondansetron injection ampules should not be autoclaved.
Compatibility studies have been carried out in polyvinyl chloride infusion bags and polyvinyl chloride administration sets. Stability is conferred by the use of polyethylene infusion bags or Type 1 glass bottles.
Dilutions of unpreserved ondansetron injection in sodium chloride 0.9% w/v or in dextrose 5% w/v have been demonstrated to be stable in polypropylene syringes. Therefore, it is considered that unpreserved ondansetron injection diluted with compatible infusion fluids recommended previously would also be stable in polypropylene syringes.
In keeping with good pharmaceutical practice, IV solutions should be prepared at the time of infusion, under appropriate aseptic conditions.