Ziprox Dosage/Direction for Use

Dosage: Usual adult dosage is 100-400mg I.V., every 12 hours.
The recommended adult dosage for urinary tract infections of mild to moderate severity is 200 mg I.V. every 12 hours. For severe or complicated urinary tract infections, the recommended dosage is 400 mg I.V. every 12 hours.
The recommended adult dosage for lower respiratory tract infections, skin and skin structure infections, and bone and joint infections of mild to moderate severity is 400 mg I.V. every 12 hours.
Duration of therapy: Duration of ciprofloxacin injection therapy is usually 7-14 day, for infections of bone and joint it is administered over 4-6 weeks or more. Also, it is administered for 2 more days after symptom is disappeared.
Ciprofloxacin is administered by intravenous injection over 60 minutes. The determination of dosage for any particular patient must take into consideration the severity and nature of the infection, the susceptibility of the causative microorganism, the integrity of the patient's host-defense mechanisms and the status of renal and hepatic function. Parenteral therapy may be changed to oral ciprofloxacin when the condition warrants, at the discretion of the physician.
Renal impairment: The following provides dosage guidelines for use in patients with renal impairment; however, monitoring of serum drug levels provides the most reliable basis for dosage adjustment.
Creatinine Clearance (mL/min) >30 mL/min: See usual adult dosage.
Creatinine Clearance (mL/min) 5-29 mL/min: 200-400 mg q 18-24 hr.