Ziproc-25/Ziproc-100 Dosage/Direction for Use

To minimize the incidence of adverse effects, clozapine therapy should be introduced gradually, beginning with low doses and increasing according to response.
Schizophrenia including reducing the risk of suicidal behavior: Usual Dose: 12.5 mg (half a 25 mg tablet) once or twice on the first day followed by 25 mg or twice on the second day. Thereafter the daily dose may be increased gradually in increments of 25 to 50 mg to achieve a daily dose of up to 300 mg within 2 to 3 weeks. Subsequent increments of 50 to 100 mg may be made once or twice weekly.
Therapeutic Dose: Most patients respond to 200 to 450 mg daily in divided doses.
Maximum Dose: Daily maximum dose of 900 mg/day should not be exceeded and should be given in divided doses.
Maintenance Dose: Once a therapeutic response has been obtained, a gradual reduction of dosage to a suitable maintenance dose may be possible. Daily maintenance dose of 200 mg or less may given as single dose in the evening.
Ending Therapy: If clozapine is to be withdrawn this should be done gradually over a 1 to 2 week period. However, immediate discontinuation with careful observation is essential if neutropenia develops or if myocarditis is suspected.
Psychoses in Parkinson's Disease: Initial Dose: Not more than 12.5 mg (half a 25 mg tablet) once daily in the evening. Subsequent increases may be made in increments of 12.5 mg, with up to 2 increases each week, a dose of 50 mg daily should not be reached before the end of the second week.
Therapeutic Dose: The usual dose ranges from 25 to 37.5 mg daily although some patients may require higher doses. Increases above 50 mg should be made at weekly intervals.
Maximum Dose: Maximum dose of 100 mg daily.
Maintenance Dose: The dose of clozapine may need to be adjusted if psychotic symptoms recur following increases in antiparkisonian therapy. The dose may be increased in weekly increments of 12.5 mg to a maximum of 100 mg daily, as a single dose or in two divided doses.
Ending Therapy: Planned withdrawal of clozapine should be gradual, in decrements of 12.5 mg over 1 to 2 weeks, in patients with Parkinson's disease. Or as prescribed by the physician.