Zicef Drug Interactions

Cephalosporin antibiotics at high dosage should be given with caution to patients receiving concurrent treatment with potent diuretics such as furosemide, aminoglycosides and amphotericin as concomitant use increases the risk of nephrotoxicity. Renal function should be monitored in these patients.
Concomitant therapy with probenecid can reduce the renal excretion of cephalosporins. Plasma concentrations are enhanced if probenecid is given concomitantly.
Since bacteriostatic drugs may interfere with the bactericidal action of cephalosporins, it is advisable to avoid giving tetracyclines, macrolides, or chloramphenicol in conjunction with cefuroxime. Urine sugar tests using reduction methods may show false positive reactions, therefore enzymatic methods should be used. Cefuroxime sodium does not interfere in enzyme-based tests for glycosuria. Slight interference with copper reduction methods (Benedict's, Fehling's, Clinitest) may be observed. However, this should not lead to false positive results, as may be experienced with some other cephalosporins.
During intravenous administration admixture with other medications in solution should be avoided. Sodium bicarbonate is not recommended for the dilution of cefuroxime.